Recording available: Pre-hospital synergy: Tranexamic acid and blood transfusion in patients at risk for haemorrhage

A partnership between UNITAR, EBRS, CAGS, and The Global Surgery Foundation

Evidence Based Review in Surgery

Discussion on the publication:

“Pre-hospital synergy: Tranexamic acid and blood transfusion in patients at risk for hemorrhage”

Date: 29 September at 4PM CET / 8AM MST

This event was an Accredited Group Learning Activity (Section 1) - scroll down for more information.

Background

Hemorrhage remains a leading cause of death after injury. Evidence-based strategies to manage the bleeding trauma patient in hospital have led to a reduction in hemorrhagic deaths, however there is less evidence to support similar pre-hospital interventions. Some strategies, such as early blood product administration and the use of tranexamic acid (TXA), may be extrapolated to the pre-hospital setting, however the utility of combining these interventions remains unknown.

The STAAMP trial was a randomized controlled trial evaluating the use of pre-hospital TXA to reduce mortality in injured patients at risk for hemorrhage. Secondary analysis of the data from this trial is presented in the article to be reviewed (Pre-hospital synergy: Tranexamic acid and blood transfusion in patients at risk for hemorrhage Deeb et al, J Trauma Acute Care Surg April 2022), which seeks to determine if receiving prehospital blood transfusion in addition to TXA is associated with a reduction in mortality. This session will provide a critical appraisal of the article, as well as clinical review of the topic by experts in the field.

Agenda

Download the agenda here.

Guiding questions

Does the currently available evidence support the combined use of TXA and blood transfusion in the pre-hospital setting for injured patients who are at risk of hemorrhage?

Objectives

Event objectives

Review the evidence supporting the use of tranexamic acid in injured patients
Review the evidence supporting pre-hospital blood transfusion in injured patients
Critically appraise an article evaluating the combined use of pre-hospital blood transfusion and tranexamic acid in injured patients

Learning objectives
 After the event, participants will be able to:

Describe the history of tranexamic acid research in injured patients
Describe the relationship between pre-hospital blood transfusion and tranexamic acid and mortality
Describe an approach to critical appraisal of a study employing secondary analysis of a randomized controlled trial

Moderator

Dr. Chad Ball, Professor of Surgery, University of Calgary

Panelists

Dr. Kelly Vogt, Associate Professor of Surgery, Western University
Dr. Nohbojit Roy, Trauma Surgeon, India
Dr. Pradeep H Navsaria, Trauma Surgeon, Trauma Center, Groote Schuur Hospital and Professor of Surgery, University of Cape Town

Target audience

Practitioners, researchers and trainees involved in the care of injured patients.

Accreditation

This event was an Accredited Group Learning Activity (Section 1) as defined by the Maintenance of Certification (MoC) Program of the Royal College of Physicians and Surgeons of Canada and approved by Canadian Association of General Surgeons. You may claim a maximum of 1 credit. The Royal College of Physicians and Surgeons of Canada MoC credits are recognized through agreement by the following international organizations:

American Medical Association (AMA)
The European Board for Accreditation in Cardiology (EBAC)
European Union of Medical Specialists - European Accreditation Council for CME (UEMS-EACCME)
Qatar Council for Healthcare Practitioners, Ministry of Public Health (QCHP)

Please contact CAGS for further information regarding the certificate at cags@cags-accg.ca.

Watch recording

This event was organised as a collaboration of